Modification of CRISPR guide RNA structure prevents immune response in target cells – Phys.Org
Phys.Org |
Modification of CRISPR guide RNA structure prevents immune response in target cells
Phys.Org In vitro transcribed-CRISPR guide RNAs trigger innate immune response in cells, but can be prevented by removing the triphosphate moiety. Credit: Sojung Kim. CRISPR-mediated genome editing has become a powerful tool for modeling of disease in various … |
