More Efficient Way to Make Pluripotent Cells from Adult Cells Reported
In a report on a new paper called Cell Stem Cell from from Children’s Hospital Boston:
“a new way to reprogram ordinary human cells into stem cells, using RNAs, appears safer and much more efficient than current methods – and can much more readily transform stem cells into specialized cells to treat disease.”
- Modified mRNAs can express reprogramming proteins and evade antiviral response
- Highly efficient derivation of human iPSCs without genomic integration
- RNA-derived iPSCs faithfully recapitulate the properties of human ESCs
- Efficient directed differentiation of iPSCs to differentiated myotubes
