R-spondin 3 is a critical regulator of gastric antral stem cell homeostasisNature.comA new study published in Nature identifies R-spondin 3, a protein released by gastric myofibroblasts, as an important regulator of gastric epithelial stem cells and an… Continue reading
Drug Discovery & Development |
Embracing the Promise of Oncolytic Virus Immunotherapy
Drug Discovery & Development Despite decades of research, and significant medical breakthroughs, cancer mortality rates remain high, while efficacious therapeutic options vary greatly across cancer types. This heterogeneity in effective treatment options is due in part to cancer’s … |
Drug Discovery & Development |
Embracing the Promise of Oncolytic Virus Immunotherapy
Drug Discovery & Development Despite decades of research, and significant medical breakthroughs, cancer mortality rates remain high, while efficacious therapeutic options vary greatly across cancer types. This heterogeneity in effective treatment options is due in part to cancer’s … |
OncLive |
FDA Puts Clinical Holds on “Off-the-Shelf” CAR–T Trials
OncLive Following the death of a 78-year-old man being treated for blastic plasmacytoid dendritic cell neoplasm (BPDCN), the FDA placed clinical holds on 2 phase I trials investigating a gene-edited allogeneic CAR T-cell (UCART) therapy known as UCART123. FDA hits Cellectis’ off-the-shelf CAR–T program with clinical hold after first patient treated in phase 1 trial diesFierceBiotech Patient Death Triggers FDA Hold For Cellectis’s “Off the Shelf” CAR–TXconomy Genetically Modified Immune Cells Have Killed a Patient, Halting Two Cutting-Edge TrialsMIT Technology Review BioPharma Dive –Genetic Engineering & Biotechnology News –P&T Community all 22 news articles » |
OncLive |
FDA Puts Clinical Holds on “Off-the-Shelf” CAR–T Trials
OncLive Following the death of a 78-year-old man being treated for blastic plasmacytoid dendritic cell neoplasm (BPDCN), the FDA placed clinical holds on 2 phase I trials investigating a gene-edited allogeneic CAR T-cell (UCART) therapy known as UCART123. FDA hits Cellectis’ off-the-shelf CAR-T program with clinical hold …FierceBiotech Patient Death Triggers FDA Hold For Cellectis’s “Off the Shelf” CAR–TXconomy Genetically Modified Immune Cells Have Killed a Patient, Halting Two Cutting-Edge TrialsMIT Technology Review BioPharma Dive –Genetic Engineering & Biotechnology News –P&T Community all 22 news articles » |
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Cancer drug research moving fast in immunotherapy field
SFGate “CAR–T therapy is in open water, vastly uncharted,” said Jay Bradner, president of Novartis Institutes for BioMedical Research, which is leading cell-therapy development at the Swiss drugmaker. “We have to make bold bets on where we can make the … |