COX-2 Inhibitors Can Improve Response to Immunotherapy of Some Cancer Tumors – Oncology Nurse Advisor
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COX-2 Inhibitors Can Improve Response to Immunotherapy of Some Cancer Tumors
Oncology Nurse Advisor Many tumor cells are resistant to immunotherapy due to IDO1 expression. In adaptive resistance, the tumor cells starts to produce IDO1 — which is associated with inflammation and T-cell infiltration — upon T-cell attack. In intrinsic resistance, the … COX-2 inhibitors may reverse IDO1-mediated immunosuppression in some cancers |
